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Reaction of Benzoyl(thioacetanilides) with α,β‐Unsaturated Nitriles; Synthesis of Functionalyzed Pyridines and Thiazoles
Author(s) -
BogdanowiczSzwed Krystyna,
CiechanowiczRutkowska Maria,
Czarny Agnieszka,
Filippini Giuseppe,
Pilati Tulio,
Rys Barbara
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419940616
Subject(s) - chemistry , piperidine , benzoyl chloride , organic chemistry , medicinal chemistry
The synthesis of spirofused 2‐thioxopyridines 3 from benzoyl(thioacetanilides) 1 and cyclohexylidenemalononitrile ( 2 ) is described. Cyclopentylidene‐ and cycloheptylidenemalononitrile do not react with 1 . Heating of 1 in the presence of piperidine yields thiazoles 4 . The structure of 4a has been established by an X‐ray analysis.