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Synthesis and X‐ray Analysis of a Sulfur Dioxide Analog of Triamterene
Author(s) -
de la Cruz Angeles,
Goya Pilar,
Páez Juan Antonio,
MartínezRipoll Martín
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419940615
Subject(s) - triamterene , chemistry , sulfur dioxide , diuretic , sulfur , inorganic chemistry , nuclear chemistry , organic chemistry , pharmacology , medicine , hydrochlorothiazide , blood pressure
The synthesis and X‐ray analysis of a sulfur dioxide analog of the diuretic agent triamterene, namely 4,7‐diamino‐1‐methyl‐6‐phenylpyrazino[2,3‐ c ][1,2,6]thiadiazine 2,2‐dioxide ( 2b ), is reported. The compound is devoid of the diuretic properties found in other related pyrazino[2,3‐ c ][1,2,6]thiadiazines.