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Enzymes in organic synthesis, 19. The enzyme‐catalyzed sequential esterification of (±)‐ anti ‐2,4‐dimethylglutaric anhydride. – An efficient route to enantiomerically enriched mono‐ and diesters of anti ‐2,4‐dimethylglutaric acid
Author(s) -
Ozegowski Rüdiger,
Kunath Annamarie,
Schick Hans
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419940218
Subject(s) - chemistry , candida antarctica , lipase , enantiomer , catalysis , enzyme , organic chemistry
(±)‐ anti ‐2,4‐Dimethylpentanedioic anhydride ( rac ‐ 1 ) was converted in good yields and with high enantiomeric excess by an enzyme‐catalyzed sequential esterification into the (2 R ,4 R )‐monoester 2 and the (2 S ,4 S )‐diester ent ‐ 3 . Best results were obtained with Novozym 435, a lipase from Candida antarctica .