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Synthesis of 4‐nitro‐1‐(trialkylsilylalkyl)imidazoles
Author(s) -
Földeák Sándor,
Molnár Mária,
Lǒkös Magdalena
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419940216
Subject(s) - chemistry , nitroimidazole , nitro , acetaldehyde , alkyl , medicinal chemistry , stereochemistry , organic chemistry , ethanol
1‐(2‐Hydroxyethyl)‐2‐methyl‐5‐nitroimidazole ( 1 ) reacts with haloalkyltrialkylsilanes [Hal(CH 2 ) n SiMe 2 R] to give 4‐nitroimidazole derivatives 3 and acetaldehyde. This process involves at least two reaction steps, N ‐alkyl quaternization and elimination of the hydroxyethyl group.
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