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Synthese von Retinoiden mit Aryltetrahydroanthracenstruktur
Author(s) -
Hanefeld Wolfgang,
Jung Manfred
Publication year - 1994
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199419940111
Subject(s) - chemistry , retinoid , stereochemistry , hypervitaminosis a , polar , retinoic acid , biochemistry , vitamin , physics , retinol , gene , astronomy
Synthesis of Retinoids with Aryltetrahydroanthracene Structure We describe the synthesis of analogues of the retinoid Temarotene (Ro 15‐0778) ( 1a ), which shows due to its lack of a polar end group no signs of hypervitaminosis A. A variety of substituted tetrahydroanthracenes 6, 8, 11, 13 is prepared starting from 2‐methoxynaphthalene ( 5b ) using palladiumcatalyzed coupling techniques.