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Unsymmetrically Substituted Furoxans, XIV. Synthesis and Structure of a Trimer of the Furoxan System with High Vasodilator and Platelet Antiaggregatory Activity
Author(s) -
Gasco Andrea Marcello,
Di Stilo Antonella,
Fruttero Roberta,
Sorba Giovanni,
Gasco Alberto,
Sabatino Piera
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199319930172
Subject(s) - furoxan , chemistry , trimer , vasodilation , nitric oxide , derivative (finance) , stereochemistry , platelet , organic chemistry , medicine , dimer , financial economics , economics
The synthesis and structure of a trimer 5 of the furoxan system are reported. The probable origin of this derivative is the dimerization of the intermediate 4‐phenyl‐3‐furoxancarbonitrile oxide ( 4 ) obtained by decomposition of the corresponding nitrolic acid 3 . The title compound shows a high level of activity as vasodilator and inhibitor of platelet aggregation.