Premium
Reactions of Organic Anions, 194. Reactions of Carbanions Generated from 2‐(Dialkylamino)‐2‐phenylacetonitriles with Disubstituted Acetylenes
Author(s) -
Zdrojewski Tadeusz,
Jończyk Andrzej
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199319930163
Subject(s) - carbanion , chemistry , sodium hydroxide , medicinal chemistry , chloride , catalysis , hydroxide , sodium , organic chemistry
Reactions of aminonitriles 1a – e with disubstituted acetylenes 2 , 3 , carried out in DMSO in the presence of powdered sodium hydroxide and benzyltriethylammonium chloride (TEBAC) as a catalyst, afford either 4 and 5 or a mixture of 4 and 6 ; unmasking of the carbonyl group in 5a and 6a gives ketones 7 and 8 , respectively.