Premium
Synthesis of Methyl 2,6‐Dideoxy‐4‐thio‐α‐ D ‐ ribo ‐hexopyranoside (methyl 4‐thiodigitoxoside) – a Constituent of the Calicheamicins and Esperamicins
Author(s) -
Claßen Arnold,
Scharf HansDieter
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199319930133
Subject(s) - chemistry , thio , stereochemistry , chain (unit) , physics , astronomy
The 4‐thio analog of 2,6‐dideoxy‐ D ‐ ribo ‐hexopyranose ( D ‐digitoxose) is part of the saccharide chain of the calicheamicins and esperamicins. A straightforward synthesis of the 4‐thiodigitoxoside 12 as its diacetate 13 starting from methyl α‐ D ‐galactopyranoside ( 1 ) is described. Properties and structure of 13 are presented.