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Aromatic and Azaaromatic Diselenides, Benzisoselenazolones and Related Compounds as Immunomodulators Active in Humans: Synthesis and Properties
Author(s) -
Młochowski Jacek,
Kloc Krystian,
Syper Ludwik,
Inglot Anna D.,
Piasecki Egbert
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1993199301201
Subject(s) - chemistry , combinatorial chemistry
Convenient syntheses of aryl diselenides 2 , 1,2‐benzisoselenazol‐3(2 H )‐ones 4 and their 1‐oxides 7 are reported. Reductive conversions of these compounds to bis(2‐carbamoyl)‐phenyl diselenides 5 and oxidative cyclization of 5 to 1,2‐benzisoselenazol‐3(2 H )‐one 1‐oxides 7 as the methods for the synthesis of these compounds are reported. Their ability to induce cytokines, such as TNF and IFN‐γ, in human peripheral blood leucocyte cultures is described.