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Thioalkylation of enolates, II. – α‐Thioalkylation of Zinc Enolates to α,α‐Disubstituted Ketones
Author(s) -
Groth Ulrich,
Huhn Thomas,
Richter Norbert
Publication year - 1993
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199319930109
Subject(s) - chemistry , zinc , diethylamine , alkylation , lithium (medication) , raney nickel , flue gas desulfurization , nickel , organic chemistry , inorganic chemistry , medicinal chemistry , catalysis , medicine , endocrinology
An α‐alkylation of the 2‐methylcycloalkanones 1 and 4 at the higher substituted carbon can be achieved by thioalkylation of the corresponding zinc enolates with the α‐chlorosulfides 3 . The desulfurization can be carried out with either Raney nickel or lithium in diethylamine for compounds which contain double or triple bonds.