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Bausteine von Oligosacchariden, CI. Synthese von modifizierten Oligosacchariden der N ‐Glycoproteine zur Untersuchung der Substratspezifität der N ‐Acetylglucosaminyltransferase II des Trimming‐Prozesses
Author(s) -
Paulsen Hans,
van Dorst Johannes A. L. M.,
Reck Folkert,
Meinjohanns Ernst
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199219920189
Subject(s) - chemistry , tetrasaccharide , stereochemistry , trimming , substrate (aquarium) , trisaccharide , glycoprotein , glycosylation , biochemistry , polysaccharide , oceanography , geology , computer science , operating system
Building Units of Oligosaccharides, CI. — Synthesis of Modified Oligosaccharides of the N ‐Glycoproteins Intended for Substrate Specificity Studies of N ‐Acetylglucosaminyltransferase II of the Trimming Process The trichloroacetimidate method was very successful for the synthesis of the tetrasaccharide octyl O ‐(2‐acetamido‐2‐deoxy‐β‐ D ‐glucopyranosyl)‐(1→2)‐ O ‐(α‐ D ‐mannopyranosyl)‐(1→3)‐ O ‐[(α‐ D ‐mannopyranosyl)‐(1→6)]‐β‐ D ‐mannopyranoside ( 10 ). Further derivatives of the tetrasaccharide with a 4‐ O ‐methyl group 20 and with a 4‐deoxy group 28 were synthesized. The tetrasaccharides are intended for substrate specificity studies of the N ‐acetylglucosaminyltransferase II of the trimming process in the biosynthesis of N ‐glycoproteins.