Antibiotics from Gliding Bacteria, XLVII. Thiangazole: A Novel Inhibitor of HIV‐1 from  Polyangium spec. | Zendy

Jansen Rolf | Zendy; Kunze Brigitte | Zendy; Reichenbach Hans | Zendy; Jurkiewicz Elke | Zendy; Hunsmann Gerhard | Zendy; Höfle Gerhard | Zendy

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Antibiotics from Gliding Bacteria, XLVII. Thiangazole: A Novel Inhibitor of HIV‐1 from Polyangium spec.

Author(s) -

Jansen Rolf,

Kunze Brigitte,

Reichenbach Hans,

Jurkiewicz Elke,

Hunsmann Gerhard,

Höfle Gerhard

Publication year - 1992

Publication title -

liebigs annalen der chemie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0170-2041

DOI - 10.1002/jlac.199219920163

Subject(s) - chemistry , bacteria , metabolite , antibiotics , derivative (finance) , stereochemistry , thiazoline , human immunodeficiency virus (hiv) , combinatorial chemistry , biochemistry , virology , biology , genetics , financial economics , economics

Using a biological screening with a HIV‐1/MT‐4 cell assay indicating antiviral activity and cell toxicity, we detected and isolated a new inhibiting metabolite from gliding bacteria, thiangazole ( 1 ). The structure of 1 was determined by spectroscopic methods to be a tris(thiazoline) derivative, showing a remarkable similarity to tantazole B ( 2 ). Chemical degradation and comparison with a synthetically prepared reference compound as well as with the degradation product from 2 furnished the (5 R ,8 S ,11 S ) configuration of the asymmetric centers in 1 .

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