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Synthese von Chlorinen aus dem roten Blutfarbstoff Hämin
Author(s) -
Haake Gerold,
Meier Axel,
Montforts FranzPeter,
Scheurich Gerhard,
Zimmermann Gottfried
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199219920159
Subject(s) - chemistry , photodynamic therapy , pigment , heme , stereochemistry , dimethylacetamide , combinatorial chemistry , biochemistry , organic chemistry , solvent , enzyme
Synthesis of Chlorins from the Red Blood Pigment Heme Hydroxyalkylporphyrins rac ‐ 8h , k and rac ‐ 9h , k prepared from the readily accessible red blood pigment heme can be transformed into the geminally dialkylated chlorins rac ‐ 10 – 13 upon reaction with N , N ‐dimethylacetamide dimethyl acetal. The chlorins are promising candidates for application in Photodynamic Tumor Therapy (PDT). The reported synthetic method should be useful for the synthesis of natural hydroporphyrins containing geminally dialkylated structural parts.