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Zur Synthese von β‐Alkyl‐α‐methylen‐γ‐butyrolactonen
Author(s) -
Röder Erhard,
Krauß Hiltrud
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199219920133
Subject(s) - chemistry , alkyl , methylene , medicinal chemistry , organic chemistry
Synthesis of β‐Alkyl‐α‐methylene‐γ‐butyrolactones The ylene 1 reacts with aldehydes to give 3‐alkylidenesuccinic acid monoethyl esters 2 , which form β‐alkylidene‐γ‐butyrolactones 3 when treated with sodium diethyldihydroaluminate. Hydrogenation of the double bond leads to the β‐alkyl‐γ‐butyrolactones 4 . The β‐alkyl‐α‐methylene‐γ‐butyrolactones 5 are obtained by Mannich reaction.