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Photochemische Studien, 64. Photostabilität von Glucocorticoiden in kristallinem Zustand
Author(s) -
Reisch Johannes,
Iranshahi Lotfollah,
EkizGücer Nurten
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1992199201197
Subject(s) - cortisone , chemistry , hydrocortisone acetate , hydrocortisone , irradiation , solid state , chromatography , nuclear chemistry , biochemistry , medicine , physics , nuclear physics
Photochemical Studies, 64. — Photostability of Glucocorticoids in the Solid State Most of the pharmacopoeia require that the glucocorticoids hydrocortisone ( 1 ), cortisone ( 2 ), hydrocortisone 21‐acetate ( 3 ) and cortisone 21‐acetate ( 4 ) must be protected from light during storage. The present study shows that UV irradiation of these compounds in the solid state leads to the loss of the side chain at C‐17. Two 17‐ketosteroids, 11β‐hydroxy‐4‐androstene‐3,17‐dione ( 6 ) and 4‐androstene‐3,11,17‐trione ( 7 ), were obtained as photoproducts (yields 3% and 4%, respectively).