Synthesis of Some Ribose‐Alkylated 5′‐UMP Derivatives | Zendy

Khan Khurshid Alam | Zendy; QudrateKhuda M. | Zendy; Fizza Kaniz | Zendy; Ahmad Viqar Uddin | Zendy

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Synthesis of Some Ribose‐Alkylated 5′‐UMP Derivatives

Author(s) -

Khan Khurshid Alam,

QudrateKhuda M.,

Fizza Kaniz,

Ahmad Viqar Uddin

Publication year - 1992

Publication title -

liebigs annalen der chemie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0170-2041

DOI - 10.1002/jlac.1992199201178

Subject(s) - chemistry , alkylation , isopropyl , methyl iodide , mass spectrometry , iodide , fast atom bombardment , nuclear magnetic resonance spectroscopy , spectroscopy , ethyl iodide , medicinal chemistry , organic chemistry , chromatography , catalysis , physics , quantum mechanics

The reaction of 5′‐UMP ( 1 ) with methyl, ethyl, n ‐propyl, and isopropyl iodide under strongly alkaline conditions gave predominantly ribose‐alkylated derivatives 2 – 11 . The structures of the products have been assigned by using UV spectroscopy, paper electrophoresis, 1 H‐NMR spectroscopy and fast‐atom bombardment mass spectrometry in the negative ion mode.

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