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Synthesis of Some Ribose‐Alkylated 5′‐UMP Derivatives
Author(s) -
Khan Khurshid Alam,
QudrateKhuda M.,
Fizza Kaniz,
Ahmad Viqar Uddin
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1992199201178
Subject(s) - chemistry , alkylation , isopropyl , methyl iodide , mass spectrometry , iodide , fast atom bombardment , nuclear magnetic resonance spectroscopy , spectroscopy , ethyl iodide , medicinal chemistry , organic chemistry , chromatography , catalysis , physics , quantum mechanics
The reaction of 5′‐UMP ( 1 ) with methyl, ethyl, n ‐propyl, and isopropyl iodide under strongly alkaline conditions gave predominantly ribose‐alkylated derivatives 2 – 11 . The structures of the products have been assigned by using UV spectroscopy, paper electrophoresis, 1 H‐NMR spectroscopy and fast‐atom bombardment mass spectrometry in the negative ion mode.