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Synthese 2‐Heteroaryl‐substituierter 3,3,3‐Trifluoralanin‐ und 3,3,3‐Trifluormilchsäure‐Derivate
Author(s) -
Sewald Norbert,
Burger Klaus
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1992199201156
Subject(s) - chemistry , nitrile , trifluoromethyl , azide , medicinal chemistry , stereochemistry , organic chemistry , alkyl
Synthesis of 2‐Heteroaryl‐Substituted 3,3,3‐Trifluoroalanine and 3,3,3‐Trifluorolactic Acid Derivatives Trifluoromethyl‐substituted alkynyl α‐amino acid as well as alkynyl α‐hydroxy acid esters and 1,3‐dipoles (nitrile oxides, diazoalkanes, phenyl azide) react regioselectively to give α‐trifluoromethyl‐substituted heterocyclic α‐amino and α‐hydroxy acid derivatives, respectively.