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Studies on the Synthesis of 3‐Vinylcephalosporins
Author(s) -
Pitlik János,
Batta Gyula,
Sztaricskai Ferenc
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1992199201148
Subject(s) - chemistry , wittig reaction , phosphonium , phosphonium salt , cleavage (geology) , combinatorial chemistry , salt (chemistry) , sequence (biology) , organic chemistry , biochemistry , geotechnical engineering , fracture (geology) , engineering
Several novel cephalosporins 4 – 19 having substituted vinyl functionalities at C‐3 were synthesized. The title compounds were prepared by a short and simple reaction sequence starting from protected 7‐aminocephalosporanic acid derivatives 1 – 3 and involving cleavage with iodotrimethylsilane, phosphonium salt formation, and subsequent Wittig reaction. The effect of the substituents are also discussed.