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Fused Heterocycles, VII. Synthesis and Stereochemistry of Tetracyclic Benzodiazepines
Author(s) -
Tóth Gábor,
Lévai Albert,
Szőllősy ÁRon
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1992199201132
Subject(s) - chemistry , acetic anhydride , anhydrous , acetylation , pyridine , ethanol , organic chemistry , stereochemistry , catalysis , biochemistry , gene
Abstract Benzodiazepines 3a – d have been synthesized by the reaction of exocyclic α,β‐unsaturated ketones 1a – d with 1,2‐phenylenediamine in hot ethanol. Acetylation of compounds 3a – d with a mixture of acetic anhydride and anhydrous pyridine affords the N ‐acetyl derivatives 4a – d . Structure and stereochemistry of the synthesized compounds have been elucidated by various NMR techniques.