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Bausteine von Oligosacchariden, CIII. Synthese von modifizierten Derivaten des Disaccharides β‐ D ‐Gal‐(1 → 3)‐α‐ D ‐GalNAc zur Untersuchung der Substratspezifität der Core‐2‐β6‐GlcNAc‐Transferase und α‐3‐Sialyltransferase der Biosynthese von O ‐Glycoproteinen
Author(s) -
Paulsen Hans,
Rutz Volker,
Brockhausen Inka
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1992199201125
Subject(s) - chemistry , disaccharide , moiety , stereochemistry , transferase , biosynthesis , galactose , sialyltransferase , substrate (aquarium) , oligosaccharide , glycoprotein , biochemistry , enzyme , oceanography , geology
Building Units of Oligosaccharides, CIII. — Synthesis of Modified Derivatives of the Disaccharide β‐ D ‐Gal‐(→3)‐α‐ D ‐GalNAc for the Examination of Substrate Specificities of Core 2‐β6‐GlcNAc‐Transferase and α‐3‐Sialyltransferase Involved in the Biosynthesis of O ‐Glycoproteins Derivatives of benzyl β‐ D ‐galactopyranosyl‐(1→3)‐2‐acet‐amido‐2‐deoxy‐α‐ D ‐galactopyranoside have been synthesized. The 6′‐, 4′‐ and 3′‐OH group of the galactose moiety as well as the 6‐ and 4‐OH and the 2‐acetamido group of the 2‐acet‐amido‐2‐deoxy‐ D ‐galactose moiety have been selectively substituted by the corresponding deoxy function. The compounds are useful in studies of the substrate specificities of the core 2‐β6‐GlcNAc‐transferase and the α3‐sialyltransferase involved in the biosynthesis of O ‐glycoproteins.