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Zur stereoselektiven Synthese von 2‐ O ‐Benzyl‐1‐ O ‐hexadecyl‐ sn ‐glycerol
Author(s) -
Bauer Friederike,
Rueß KlausPeter,
Liefländer Manfred
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199219920110
Subject(s) - chemistry , glycerol , ether , alkyl , yield (engineering) , medicinal chemistry , organic chemistry , metallurgy , materials science
Stereoselective Synthesis of 2‐ O ‐Benzyl‐1‐ O ‐hexadecyl‐ sn ‐glycerol Due to the versatility of 2‐ O ‐benzyl‐1‐ O ‐hexadecyl‐ sn ‐glycerol ( 7 ) as building block for various alkyl ether lipids and alkyl ether lyso ‐lipids, 7 was prepared from D ‐mannit following two different strategies. The final product 7 was obtained either via the intermediate 1,2‐ O ‐isopropylidene‐ sn ‐glycerol ( 1 ) or via 3,4‐ O ‐isopropylidene‐ D ‐mannit ( 8 ) in an overall yield of 6% or 11%, respectively.