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Synthese und Reaktivität von 3‐Oxazolinen
Author(s) -
Weber Maya,
Jakobxht Jürgen,
Martens Jürgen
Publication year - 1992
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199219920102
Subject(s) - chemistry
Synthesis and Reactivity of 3‐Oxazolines. 3‐Oxazolines 1 have been prepared from α‐hydroxy aldehydes, ammonia, water and a second oxo compound (aldehyde or ketone) in a one‐pot reaction. Carboxylic acid chlorides add to the azomethine bond of 1 to yield 3‐acyl‐4‐chlorooxazolidines 2 . 4‐Hydroxy and 4‐alkoxyoxazolidines 3 are obtained from 2 upon treatment with aqueons sodium hydroxide or alkanol/ triethyl amine, respectively. Some oxazolidines 3 are formed with high diastereoseselectivity.