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1,2,4‐Dithiazoliumsalze als Ausgangsstoffe für Pyrimidinderivate mit Oxo‐, Thioxo‐ oder Aminofunktion in 4‐Stellung
Author(s) -
Briel Detlef
Publication year - 1991
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199119910160
Subject(s) - chemistry , ring (chemistry) , ammonium acetate , pyrimidine , medicinal chemistry , transformation (genetics) , condensation reaction , combinatorial chemistry , stereochemistry , organic chemistry , high performance liquid chromatography , biochemistry , catalysis , gene
Synthesis of Pyrimidine Derivatives Having Oxo, Thioxo or Amino Functions at Position 4 from 1,2,4‐Dithiazolium Salts The (thioaroylamido)acrylonitriles 2 , obtained by reaction of 1,2,4‐dithiazolium salts 1 with ethyl cyanacetate, undergo ring transformation reactions by reaction with ammonium acetate, primary and secondary amines and form the pyrimidines 7–9 . A possible mechanism for these reactions is discussed.