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Enzym‐katalysierte Reaktionen, 8. Stereoselektive Darstellung von 2‐Aminoalkoholen aus (R)‐ und (S)‐Cyanhydrinen
Author(s) -
Effenberger Franz,
Gutterer Beate,
Ziegler Thomas
Publication year - 1991
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199119910145
Subject(s) - chemistry , stereoselectivity , trimethylsilyl cyanide , stereochemistry , diastereomer , trimethylsilyl , catalysis , organic chemistry
Enzyme‐Catalyzed Reactions, 8. – Stereoselective Synthesis of 2‐Amino Alcohols from (R)‐ and (S)‐Cyanohydrins erythro‐2‐Amino alcohols (1R,2S)‐ and (1S,2R)‐ 4 may be synthesized stereoselectively by addition of Grignard compounds to cyanohydrins (R)‐, (S)‐ 1 and their O‐trimethylsilyl derivatives 3 , respectively, followed by hydrogenation. The threo‐2‐amino alcohols (1S,2S)‐ and (1R,2R)‐ 4 are easily accessible by inversion at C‐1 of the (1R,2S) and (1S,2R) compounds.