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Synthese von 5,15‐diarylsubstituierten Porphyrinen über Aminomethylierung von Bis(4‐ethyl‐3‐methyl‐2‐pyrryl)phenylmethanen
Author(s) -
Hombrecher Hermann K.,
Horter Gaby
Publication year - 1991
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199119910139
Subject(s) - chemistry , reagent , acetonitrile , mannich reaction , medicinal chemistry , organic chemistry , catalysis
Synthesis of 5,15‐Diaryl‐Substituted Porphyrins by Aminomethylation of Bis(4‐ethyl‐3‐methyl‐2‐pyrryl)phenylmethanes The synthesis of unsymmetrically diarylsubstituted porphyrins 11a‐g (yields 5–19%) is described. Aminomethylation of dipyrromethane 6a with Mannich reagent 9 in acetonitrile leads to the intermediate 10 , which is directly converted into the porphyrins 11 by acid‐catalysed coupling with the dipyrromethanes 6 .