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Studies on Isocyanides and Related Compounds. Synthesis of Oxazole Derivatives via the Passerini Reaction
Author(s) -
Bossio Ricardo,
Marcaccini Stefano,
Pepino Roberto
Publication year - 1991
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1991199101193
Subject(s) - oxazole , chemistry , isocyanide , aryl , combinatorial chemistry , organic chemistry , stereochemistry , alkyl
The reaction between arylglyoxals ( 1 ), cyclohexyl isocyanide, and aromatic carboxylic acids ( 2 ) affords N ‐cyclohexyl‐2‐acyloxy‐3‐aryl‐3‐oxopropionic amides ( 3 ) which can be cyclized to N ‐cyclohexyl‐2,4‐diaryl‐5‐oxazolecarboxamides ( 4 ).