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Preparation of enantiomerically pure pyrazolines by an enantioconvergent process
Author(s) -
BosumDybus Annegrit,
Neh Harribert
Publication year - 1991
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1991199101139
Subject(s) - diastereomer , chemistry , regioselectivity , derivatization , pyrazoline , organic chemistry , cleavage (geology) , high performance liquid chromatography , catalysis , geotechnical engineering , fracture (geology) , engineering
Derivatization of insecticidally active rac ‐pyrazoline 2 with (1 S )‐(−)‐camphanic acid chloride led to the separable diastereomers 3a and 3b . Regioselective cleavage to the enantiomerically pure pyrazolines 2a and 2b was achieved under mild conditions. Diastereomer 3b was transformed into diastereomer 3a by crystallization under equilibrating conditions making the overall process enantioconvergent.