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Synthesis of isoquinoline alkaloids. Total synthesis of (±)‐tetrahydroescholamine and its (±)‐threo‐ and (±)‐erythro‐α‐hydroxy analogs
Author(s) -
Rozwadowska Maria D.,
Matecka Dorota,
Brózda Danuta
Publication year - 1991
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199119910113
Subject(s) - isoquinoline , chemistry , diastereomer , salt (chemistry) , total synthesis , lithium (medication) , chloride , dithiane , stereochemistry , medicinal chemistry , organic chemistry , medicine , endocrinology
The studied tetrahydroisoquinolines 1, 2 and 3 were synthesized from a common intermediate 6 , which was prepared by addition of the lithium salt of dithiane 5 to hydrastinine chloride ( 4 ).