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Antibiotics from gliding bacteria, XLIII. Phenoxan: A novel inhibitor of HIV‐1 infection in cell cultures from Polyangium sp. , strain Pl VO19 (Myxobacteria)
Author(s) -
Jansen Rolf,
Kunze Brigitte,
Wray Victor,
Reichenbach Hans,
Jurkiewicz Elke,
Hunsmann Gerhard,
Höfle Gerhard
Publication year - 1991
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1991199101125
Subject(s) - myxobacteria , bacteria , antibiotics , microbiology and biotechnology , chemistry , strain (injury) , human immunodeficiency virus (hiv) , stereochemistry , virology , biology , genetics , anatomy
Guided by a biological screening with a cell assay, the first HIV‐1 inhibitor from a gliding bacterium, phenoxan ( 1 ), was isolated. The structure of 1 was determined by spectroscopic methods to be a substituted oxazole‐γ‐pyrone, showing a remarkable similarity to aureothin ( 2 ) and spectinabilin ( 3 ).