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Synthese von ( R )‐Lasiodiplodin aus Polyhydroxybuttersäure
Author(s) -
Braun Manfred,
Mahler Ulrike,
Houben Sabine
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199019900198
Subject(s) - depolymerization , chemistry , metabolite , biopolymer , stereochemistry , organic chemistry , biochemistry , polymer
Synthesis of ( R )‐Lasiodiplodin from Polyhydroxybutyric Acid The twelve‐membered macrolide ( R )‐lasiodiplodin ( 1 ), a fungal metabolite of Botrysdiplodia theobromae , has been synthesized in a nine‐step procedure. ( R )‐1,3‐Butanediol ( 6 ), which is easily available by reductive depolymerization of the biopolymer polyhydroxybutyric acid (PHB), proves itself as a suitable enantiomerically pure building block.