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Investigation of the one‐pot synthesis of N ‐(5,6,7,8‐tetrahydro‐7,7‐dimethyl‐2,5‐dioxo‐2 H ‐1‐benzopyran‐3‐yl‐2,5‐dioxo‐2 H ‐1‐benzopyran‐3‐yl)benzamide
Author(s) -
Kočevar Marijan,
Polanc Slovenko,
Verček Bojan,
Tišler Miha
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199019900195
Subject(s) - dimedone , benzopyran , chemistry , triethyl orthoformate , acetic anhydride , derivative (finance) , hippuric acid , organic chemistry , acetic acid , medicinal chemistry , catalysis , urine , biochemistry , financial economics , economics
A detailed investigation of the reaction of hippuric acid ( 2 ) with dimedone ( 1 ) and triethyl orthoformate or other one‐carbon sources in acetic anhydride yielding the benzopyran derivative 3 and many byproducts is described. An explanation of this complex process, several attempts to optimize it, and some new approaches to 3 are given.