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Synthesis of 2‐alkyl‐3‐vinyloxaziridines as potential antitumor agents
Author(s) -
Said Samy B.,
Młochowski Jacek,
Skarżewski Jacek
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199019900187
Subject(s) - chemistry , oxaziridine , aldimine , alkyl , in vitro , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , catalysis
A convenient method for the synthesis of previously unknown oxaziridines having unsaturated substituents at the 3‐position ( 3a – k ) is based on the selective oxidation of the imino group of α,β‐unsaturated aldimines 2 with m ‐chloroperbenzoic acid. The title compounds and 2‐ tert ‐butyl‐3‐(phenylethynyl)oxaziridine ( 3k ) exhibit potent activity against experimental tumor cells in vitro.