Synthesis of polyfunctionally substituted pyridazines | Zendy

Ghozlan Said Ahmed Soliman | Zendy; Mohamed Mona Hassan | Zendy; Fakhr Yehia | Zendy; Elnagdi Mohamed Hilmy | Zendy

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Synthesis of polyfunctionally substituted pyridazines

Author(s) -

Ghozlan Said Ahmed Soliman,

Mohamed Mona Hassan,

Fakhr Yehia,

Elnagdi Mohamed Hilmy

Publication year - 1990

Publication title -

liebigs annalen der chemie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 0170-2041

DOI - 10.1002/jlac.199019900153

Subject(s) - chemistry , malononitrile , pyridazine , hydrochloride , sodium ethoxide , reagent , acetic acid , hydrazone , hydrochloric acid , hydrazine (antidepressant) , hydroxylamine , acetic anhydride , organic chemistry , hydroxylamine hydrochloride , medicinal chemistry , chromatography , catalysis , ethanol

The pyridazines 3 , 4 , 5 , and 7 were obtained by reaction of the hydrazone derivatives 2 with several reagents. By treatment of 5 with acetic acid/hydrochloric acid, the pyrazolo[4,3‐ c ]‐pyridazine 6 was formed. The pyrido‐pyridazine derivatives 8 and 9 were obtained by reaction of 2 and 3 with malononitrile and ethyl cyanoacetate, respectively, and the isoxazolo‐pyridazines 11 by reaction of 3a , b with hydroxylamine hydrochloride in ethanolic sodium ethoxide solution. The intermediate 9 was separated by reaction of 3a , b with hydroxylamine hydrochloride in ethanolic sodium acetate solution.

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