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Novel, diastereoselective synthesis of 3‐amino‐1‐alkanols
Author(s) -
Oszbach György,
Neszmélyi András
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199019900138
Subject(s) - chemistry , benzaldehyde , ketone , nuclear magnetic resonance spectroscopy , stereochemistry , organic chemistry , catalysis
Benzaldehyde adds to 1‐pyrrolidinylcyclohexene under mild conditions giving the amino ketone 3a . The unstable ketone was reduced to the epimeric alcohols 4 and 5 , the stereochemistry of which was determined by 2D‐NMR correlation spectroscopy.