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Enzymatische Acetylierung von (±)‐1‐Phthalimido‐2‐propanol
Author(s) -
Jeromin Günter E.,
Weise Sven
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1990199001188
Subject(s) - chemistry , acetylation , propanol , propane , derivative (finance) , optically active , enzyme , 1 propanol , organic chemistry , medicinal chemistry , stereochemistry , methanol , biochemistry , financial economics , economics , gene
Enzymatic Acetylation of (±)‐1‐Phthalimido‐2‐propanol 1‐Phthalimido‐2‐propanol [(±)‐ 1 ] is an N ‐protected derivative of 1‐amino‐2‐propanol. By irreversible enzymatic acetylation of the racemate (±)‐ 1 , (+)‐2‐acetoxy‐1‐(phthalimido)propane [(+)‐ 2 ] and (+)‐1‐phthalimido‐2‐propanol [(+)‐ 1 ] have been isolated on a preparative scale in good optical and chemical yields. Both optically active compounds are useful chiral intermediates.