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Darstellung 2‐methoxysubstituierter Pyrrole durch intramolekulare Aza‐Wittig‐Reaktionen
Author(s) -
Montforts FranzPeter,
Schwartz Ulrich Manfred,
Maib Piotr,
Mai Gerhard
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1990199001187
Subject(s) - chemistry , wittig reaction , intramolecular force , azide , medicinal chemistry , knoevenagel condensation , sodium azide , nucleophile , ring (chemistry) , malonate , organic chemistry , catalysis
Preparation of 2‐Methoxy‐Substituted Pyrroles by Aza‐Wittig Reactions α‐Halo ketones and dimethyl malonate can be transformed by Knoevenagel condensation and nucleophilic displacement of halogen with sodium azide into the azide esters 10 . These azides undergo ring closure to 2‐methoxy‐substituted pyrroles 11 by intramolecular Aza‐Wittig reaction.