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Stereoselektive Totalsynthese von rac ‐Yohimb‐15‐enon
Author(s) -
Rosenmund Peter,
Brandt Bernhard,
Flecker Peter,
Hoffmann Eberhard
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1990199001161
Subject(s) - chemistry , annulation , stereoselectivity , stereochemistry , total synthesis , yohimbine , catalysis , organic chemistry , biochemistry , antagonist , receptor
Stereoselective Synthesis of rac ‐Yohimb‐15‐enone The Robinson annulation of an octahydroindolo[2,3‐α]quinolizin‐2‐one is a general concept for the synthesis of yohimbine alkaloids. Using the phenylsulfonyl group for activation, a diastereoselective synthesis of rac ‐yohimben‐17‐one 21 has been developed. A new synthesis of aromatic amines 23 and 24 has been discovered.