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4,5‐dihydroisoxazoles, IX. Reactions of 3‐aryl‐4,5‐dihydro‐4‐methylene‐5‐morpholinoisoxazoles with 2,4‐diaryl‐5(4 H )‐oxazolones: A new synthesis of tetrahydro‐6‐oxo‐3‐pyridinecarbaldehydes
Author(s) -
Erba Emanuela,
Pocar Donato
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1990199001160
Subject(s) - chemistry , methylene , yield (engineering) , aryl , medicinal chemistry , organic chemistry , alkyl , materials science , metallurgy
The 5(4 H )‐oxazolones 1a – e react with 5‐morpholinoisoxazoles 2a – b to afford the 4‐[(4‐isoxazolyl)methyl]‐5(4 H )‐oxazolones 3a – g . Compounds 3 are hydrogenated with Pd/C in dioxane to yield the corresponding 1,4,5,6‐tetrahydro‐6‐oxo‐3‐pyridinecarbaldehydes 6a – d .