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Synthesis and structure of some condensed quinazolines
Author(s) -
Badawy Mohamed A.,
AbdelHady Sayed A.,
Mahmoud Ahmed H.,
Ibrahim Yehia A.
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1990199001151
Subject(s) - chemistry , quinazolinone , deamination , reagent , tricyclic , condensation , combinatorial chemistry , stereochemistry , organic chemistry , medicinal chemistry , physics , thermodynamics , enzyme
Abstract Condensation of 2‐hydrazino‐4(3 H )‐quinazolinone ( 1 ) with bielectrophilic reagents gives the corresponding triazoloquinazolines 8 , the structures of which were established by selective synthesis through deamination of their N ‐amino derivatives. The synthesis of methyl‐substituted derivatives of these angular tricyclic systems and their linear isomers was also achieved starting with 3‐methyl‐ and 1‐methyl‐2‐hydrazino‐quinazolinone.