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A simple high‐yielding synthesis of spiro[cyclopropane‐1,2′‐steroids]
Author(s) -
Desai Umesh R.,
Trivedi Girish K.
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1990199001135
Subject(s) - cyclopropane , methylene , chemistry , moiety , iodide , stereochemistry , organic chemistry , combinatorial chemistry , ring (chemistry)
A high‐yielding synthesis of biologically active spiro‐[cyclopropane‐1,2′‐steroids] with a Δ 4 ′‐3′‐one moiety by using the Simmons Smith reaction is described. 2‐Methylene‐4‐en‐3‐one steroids are treated with methylene iodide (ratio 1:1).