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Semisynthetische Myxovirescine: Austausch des α‐Hydroxycarbonsäure‐Segments und Modifikation der Ringgröße
Author(s) -
Borgschulte Katrin,
TrowitzschKienast Wolfram,
Höfle Gerhard
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.199019900111
Subject(s) - chemistry , ring (chemistry) , stereochemistry , yield (engineering) , alkyl , organic chemistry , metallurgy , materials science
Semisynthetic Myxovirescins: Exchange of the α‐Hydroxycarboxylic Acid Segment and Modification of the Ring Size Partial degradation reactions of the macrocyclic lactam‐lacton antibiotic myxovirescin A 1 ( 1 ) yield the key building blocks 2 and 26 . From these myxovirescin analoga are reconstituted with various alkyl groups at position C‐2 with R and S configuration. Furthermore a ring‐contracted ( 24 ) and a ring‐enlarged ( 29 ) macrocycle are synthesized. The growth of E. coli is best inhibited by the natural myxovirescin A 1 with a (2S) propyl substitution whilst 24 and 29 do not inhibit the growth of E. coli at all.