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Metabolic products of microorganisms, 256. Pyrrolams, new pyrrolizidinones produced by Streptomyces olivaceus
Author(s) -
Grote Ralph,
Zeeck Axel,
Stümpfel Joachim,
Zähner Hans
Publication year - 1990
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1990199001100
Subject(s) - pyrrolizidine , microorganism , chemistry , streptomyces , proline , stereochemistry , biochemistry , bacteria , biology , amino acid , genetics
Pyrrolams A to D ( 1 – 4 ), biosynthetically new pyrrolizidinones produced by Streptomyces olivaceus , have been discovered by chemical screening. Their structures have been determined by spectroscopic methods and by a comparison of ( R )‐dihydropyrrolam A ( 5 ) with a synthetic sample obtained from ( S )‐proline. The pyrrolams differ from the necine bases found in plant‐originating pyrrolizidine alkaloids by their less complicated structures.