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Studies with Alkylheteroaromatic π‐Deficient Compounds: Novel Synthesis of Thieno[3,4‐ d ]pyridazines and Phthalazines
Author(s) -
Elnagdi Mohamed Hilmy,
Negm Abdalla Mohamed,
Erian Ayman Wahba
Publication year - 1989
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198919890298
Subject(s) - chemistry , yield (engineering) , aryl , sulfur , organic chemistry , medicinal chemistry , alkyl , materials science , metallurgy
Ethyl 1‐aryl‐5‐cyano‐1,6‐dihydro‐4‐methyl‐6‐oxo‐3‐pyridazinecarboxylates 1 react with elemental sulphur in ethanolic basic solutions to yield thieno[3.4‐ d ]pyridazines 2 . Compounds 2 readily react with electron‐deficient olefins to yield phthalazines.