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Condensed Purines, I Synthesis of 6,7‐Dihydro‐1,3‐dimethylpyrimido[2,1‐ f ]purine‐2,4,8(1 H ,3 H ,9 H )‐triones
Author(s) -
Kalcheva Veneta,
Stoyanova Diana,
Simova Svetlana
Publication year - 1989
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198919890297
Subject(s) - chemistry , acrylate , theophylline , methyl acrylate , elemental analysis , purine , catalysis , purine metabolism , methacrylate , medicinal chemistry , stereochemistry , polymer chemistry , organic chemistry , polymerization , polymer , copolymer , medicine , endocrinology , enzyme
The title compounds 2a–d and 4a–d are the sole products of the reaction between 8‐aminotheophylline ( 1 ) or 8‐(benzylamino)theophylline ( 3 ) and methyl acrylate, crotonate, methacrylate, and cinnamate in the presence of basic catalysts (Triton B or KOH). The structures of the compounds were determined by elemental analysis, spectral data, chemical transformations, and synthesis.