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Synthesis of a Renin Inhibitor of the Azapeptide Type
Author(s) -
Gante Joachim,
Kahlenberg Harald
Publication year - 1989
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198919890273
Subject(s) - chemistry , carbodiimide , isocyanate , hydrazine (antidepressant) , residue (chemistry) , derivative (finance) , renin inhibitor , combinatorial chemistry , stereochemistry , renin–angiotensin system , organic chemistry , biochemistry , medicine , blood pressure , polyurethane , financial economics , economics , radiology
The azapeptide derivative 12 is obtained in a 7‐step synthesis by coupling the components 5 and 11 in the last step. Whereas the azaamino acid residue in 5 is generated by a hydrazine/isocyanate addition, the other coupling steps are done using the carbodiimide/HOBt method. Compound 12 could be shown to inhibit the enzyme renin.