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A New Synthesis of (‐)‐Biopterin Employing 5‐Deoxy‐ L ‐ribose as a Key Intermediate
Author(s) -
Mori Kenji,
Kikuchi Haruhiko
Publication year - 1989
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.1989198902102
Subject(s) - chemistry , ribose , iodide , stereoselectivity , biopterin , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , catalysis , cofactor , enzyme , tetrahydrobiopterin
(‐)‐Biopterin ( 1 ) was synthesized from 5‐deoxy‐ L ‐ribose ( 6 ) which was derived from commercially available D ‐ribose ( 2 ) employing the highly stereoselective Grignard reaction of 2,3‐ O ‐cyclohexylidene‐ D ‐ribose ( 3 ) with methylmagnesium iodide.
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