Premium
Pyridazines, XLIV. Novel Heteroaromatic Analogues of o ‐Aminobenzophenones ‐ Preparation and Cyclization to Diazaacridone Derivatives
Author(s) -
Grabenwöger Monika,
Haider Norbert,
Heinisch Gottfried
Publication year - 1989
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198919890184
Subject(s) - chemistry , regioselectivity , acetic anhydride , sodium hydroxide , aqueous solution , organic chemistry , combinatorial chemistry , catalysis
A variety of 2‐(alkylamino)phenyl 4‐pyridazinyl ketones ( 3a–e ) was prepared. The novel compounds were found to cyclize with remarkable regioselectivity upon treatment either with acetic anhydride or aqueous sodium hydroxide, giving 5‐alkylpyridazino‐[4,5‐ b ]quinolin‐10(5 H )‐ones ( 5a–e ).