Premium
Synthesis of Novel N ‐[2‐(1 H ‐Azol‐1‐yl)‐1‐arylethylidene]methanamine N ‐Oxides
Author(s) -
Mullen George B.,
Bennett Grace A.,
Swift Patricia A.,
Kuipers William J.,
Georgiev Vassil S T.
Publication year - 1989
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198919890167
Subject(s) - chemistry , stereochemistry , medicinal chemistry
The synthesis and configurational purity of a series of novel N ‐[2‐(1 H ‐azol‐1‐yl)‐1‐arylethylidene]methanamine N ‐oxides 9a–q and 10a, b is reported. Directly after the synthesis, ketonitrones 9, 10 were found to exist exclusively in the ( E ) form, although the C ‐methyl analogues 10a and 10b contained a small amount of the corresponding ( Z ) isomer. The 200‐MHz 1 H‐NMR chemical shifts of 9, 10 are also discussed.