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Diazepines, 27. Effects of Substituents on the Bromination of 2,3‐Dihydro‐1,4‐diazepinium Salts
Author(s) -
Butler Anthony R.,
Lloyd Douglas,
McNab Hamish,
Tucker Kanwaljit S.,
Marshall Donald R.
Publication year - 1989
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198919890127
Subject(s) - chemistry , halogenation , substituent , steric effects , vicinal , ring (chemistry) , medicinal chemistry , stereochemistry , organic chemistry
Bromination at the 6‐position of 2,3‐dihydro‐1,4‐diazepinium salts 1 or at the p ‐position of a 6‐phenyl substituent is subject to steric hindrance, not only by substituents at vicinal sites in the ring(s), but also by substituents at the 1‐, 2‐, and 4‐positions.