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Synthese neuartiger triazoloanellierter 8‐Azapurine
Author(s) -
Ried Walter,
Laoutidis Joannis
Publication year - 1988
Publication title -
liebigs annalen der chemie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 0170-2041
DOI - 10.1002/jlac.198819881118
Subject(s) - triethyl orthoformate , chemistry , hydrate , hydrazine (antidepressant) , yield (engineering) , polymer chemistry , organic chemistry , medicinal chemistry , catalysis , materials science , biochemistry , metallurgy
Synthesis of New Triazolo‐Annulated 8‐Azapurines Treatment of the 5‐amino‐4‐cyano‐1,2,3‐triazoles 1a – f with triethyl orthoformate and orthoacetate 2 gives the ethoxymethyleneamino‐1,2,3‐triazoles 3a – f which react with hydrazine hydrate at room temperature to yield the 1‐amino‐6‐imino‐8‐azapurines 4a – f . The pyrimidines 6a – I are obtained from 4a – f by reaction with triethyl orthoacetate and orthoformate 5 .